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Seek immediate medical attention for symptoms of serious allergic reactions (rash, swelling of the face or throat, breathing difficulties) or severe skin blistering

Safety monitoring includes periodic checks of blood glucose, thyroid function, and adrenal function, as well as watching for any adverse effects

When used in topical formulations, the most commonly reported issues are localised and mild, and may include: Skin irritation or redness at the site of application Contact dermatitis in individuals with sensitive skin or known peptide sensitivities Scalp itching or tingling , which may be transient The following precautions are advised: Avoid application to broken, inflamed, or irritated skin , and keep the product away from the eyes and mucous membranes

Foods rich in B12 include animal-based products

Cutaneous overproduction of melanin may be associated with a variety of mechanisms, but most commonly with increased sun exposure